Domaine Desom began in 1925 as a trading company founded by Peter and Albert Desom, who bought a historic building in Remich, Luxembourg. Initially, they sold products such as wine and eau-de-vie. The company expanded into wine production, developing two lines: Domaine Desom (wines from their own vineyards) and Caves Desom (wines from other winemakers). This transition to wine production laid the foundation for the modern, renowned winery, which continued to grow after a renovation in 2003 and is today known as for its high-quality wines and crémants.